EORTC‐QLQ‐C30 and SKINDEX‐29 measurement of health‐related quality of life in patients with mycosis fungoides and Sézary syndrome: Real‐world data in Spanish patients (MICADOS Study)

Background Few studies have explored the impact of cutaneous T-cell lymphoma (CTCL) on health-related quality life (HRQoL) and compared it to other patients with cancer. Objectives The primary objective study was assess QoL diagnosed mycosis fungoides (MF) Sézary syndrome (SS) types CTCL in Spain. Methods A cross-sectional observational completed recruiting adult MF SS, exploring European Organisation for Research Treatment Cancer-Core Quality Life Questionnaire, version 3 (EORTC-QLQ-C30v3) Skindex-29 HRQoL itching intensity. Results total 141 [81 males (57.4%) mean age 63.6 years (95% CI: 61.4–65.7)], were included. EORTC-QLQ-C30 global health status showed worse scores healthy population (p < 0.05) did not differ from physical role functioning better than cancer but 0.05). social similar In status, observed aging = 0.023) Eastern Cooperative Oncology Group (ECOG)-1 versus ECOG-0 0.01). score 28.5 24.8–32.3), being worst at higher clinical stage pruritus intensity 0.001) older 0.001). More related female sex 0.016), younger 0.035), ECOG m-SWAT 0.006). Conclusions These results allow mapping affectation patients. Global MF/SS like age-matched population. highest associated young age, ECOG, disease stage.